Helen E Scharfman Selected Research

Status Epilepticus (Complex Partial Status Epilepticus)

10/2023	Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
7/2023	Increasing adult neurogenesis protects mice from epilepsy.
10/2022	Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy.
1/2019	Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.
12/2017	Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats.
7/2015	Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.
11/2011	Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.
9/2009	A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
12/2008	Seizures and reproductive function: insights from female rats with epilepsy.
7/2007	Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures.

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Helen E Scharfman Research Topics

Disease

34	Seizures (Absence Seizure) 11/2023 - 04/2002
23	Epilepsy (Aura) 01/2023 - 09/2004
15	Status Epilepticus (Complex Partial Status Epilepticus) 10/2023 - 04/2002
12	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 02/2005
8	Temporal Lobe Epilepsy 10/2023 - 09/2002
3	Nervous System Diseases (Neurological Disorders) 11/2017 - 12/2006
2	Cognitive Dysfunction 01/2021 - 08/2012
2	Edema (Dropsy) 06/2010 - 01/2004
2	Mental Disorders (Mental Disorder) 12/2006 - 02/2005
1	Down Syndrome (Down's Syndrome) 01/2023
1	Angelman Syndrome (Syndrome, Angelman) 01/2021
1	Brain Injuries (Brain Injury) 01/2019
1	Post-Traumatic Epilepsy (Epilepsy, Post Traumatic) 12/2013
1	Schizophrenia (Dementia Praecox) 08/2012
1	Hypothyroidism 03/2012
1	Neurodevelopmental Disorders 03/2012
1	Contusions 06/2010
1	Spinal Cord Injuries (Spinal Cord Injury) 06/2010
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 12/2008
1	Body Weight (Weight, Body) 12/2008
1	Migraine Disorders (Migraine) 07/2008
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2008
1	Chronic Pain 09/2004
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2004
1	Brain Ischemia (Cerebral Ischemia) 01/2004
1	Inflammation (Inflammations) 01/2004

Drug/Important Bio-Agent (IBA)

20	Pilocarpine (Ocusert)FDA LinkGeneric 10/2023 - 04/2002
9	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2023 - 04/2002
6	Estrogens (Estrogen)FDA Link 09/2010 - 02/2005
5	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2004
5	ConvulsantsIBA 07/2023 - 04/2002
5	Kainic Acid (Kainate)IBA 01/2023 - 09/2002
5	Anticonvulsants (Antiepileptic Drugs)IBA 02/2015 - 12/2008
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 09/2012
3	Biomarkers (Surrogate Marker)IBA 11/2023 - 11/2018
3	Cholinergic Agents (Cholinergics)IBA 10/2023 - 09/2009
3	Gonadal HormonesIBA 07/2015 - 09/2006
3	Hormones (Hormone)IBA 09/2010 - 09/2006
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2008 - 01/2004
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 11/2017
2	SteroidsIBA 12/2014 - 09/2006
2	Nerve Growth Factors (Neurotrophins)IBA 01/2013 - 03/2012
2	Testosterone (Sustanon)FDA Link 09/2010 - 12/2008
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2008 - 01/2004
2	Neuropeptide YIBA 07/2008 - 01/2006
2	Progesterone FDA LinkGeneric 09/2006 - 11/2005
1	Cholecystokinin (Pancreozymin)IBA 10/2023
1	Tamoxifen FDA LinkGeneric 07/2023
1	Choline (Choline Chloride)IBA 05/2023
1	LithiumIBA 01/2023
1	CannabidiolIBA 01/2023
1	Presenilin-2IBA 01/2023
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2021
1	LigandsIBA 01/2021
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2021
1	CationsIBA 01/2021
1	Atropine FDA LinkGeneric 01/2021
1	Insulin-Like PeptidesIBA 01/2021
1	IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA 01/2021
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2020
1	ChromatinIBA 01/2020
1	Amyloid beta-PeptidesIBA 01/2020
1	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 01/2019
1	Calbindin 1IBA 11/2017
1	CalbindinsIBA 11/2017
1	Calcium-Binding ProteinsIBA 11/2017
1	Histones (Histone)IBA 11/2017
1	Ethosuximide (Zarontin)FDA LinkGeneric 02/2015
1	gamma-Aminobutyric Acid (GABA)IBA 01/2014
1	Peptides (Polypeptides)IBA 09/2012
1	Sodium Channels (Sodium Channel)IBA 09/2012
1	Peptide Hydrolases (Proteases)FDA Link 09/2012
1	Thyroid HormonesIBA 03/2012
1	PotassiumIBA 11/2011
1	Aquaporins (Water Channels)IBA 06/2010
1	Diazepam (Valium)FDA LinkGeneric 12/2008
1	Estradiol (Delestrogen)FDA LinkGeneric 07/2008
1	GlycogenIBA 07/2007
1	Glycogen Phosphorylase (Phosphorylase, Glycogen)IBA 07/2007
1	4-chlorokynurenineIBA 07/2005
1	ProdrugsIBA 09/2002
1	AlbuminsIBA 04/2002

Therapy/Procedure

3	Therapeutics 11/2017 - 08/2009
1	Subcutaneous Injections 01/2021
1	Cognitive Training 08/2012